The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2017
Filed:
Aug. 05, 2012
James C. Cicciarelli, Rolling Hills, CA (US);
Noriyuki Kasahara, Los Angeles, CA (US);
Christopher R. Logg, South Pasedena, CA (US);
James C. Cicciarelli, Rolling Hills, CA (US);
Noriyuki Kasahara, Los Angeles, CA (US);
Christopher R. Logg, South Pasedena, CA (US);
NATIONAL INSTITUTE OF TRANSPLANTATION FOUNDATION, Los Angeles, CA (US);
Abstract
A method can include making one or more compositions for altering allogeneic cells of a human donor for a human recipient by identifying at least one mismatch in an HLA protein between the human donor and the human recipient; determining a consensus conserved nucleic acid sequence among nucleic acid sequences encoding a domain having the mismatch or among domains having a plurality of mismatches; and forming at least one of the one or more compositions by constructing a virus vector for expressing a sequence targeting the consensus conserved nucleic acid sequence, which when expressed in cells functions as a negative modulator for nucleic acid encoding the domain having the mismatch or the domains having the plurality of mismatches.