The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 13, 2017

Filed:

May. 26, 2015
Applicant:

Promega Corporation, Madison, WI (US);

Inventors:

Thomas Kirkland, Atascadero, CA (US);

Keith V. Wood, Mount Horeb, WI (US);

Mary Hall, Waunakee, WI (US);

Marie Schwinn, Madison, WI (US);

Assignee:

PROMEGA CORPORATION, Madison, WI (US);

Attorney:
Int. Cl.
CPC ...
C07D 253/075 (2006.01); C07D 487/04 (2006.01); A61K 31/53 (2006.01); A61K 31/4985 (2006.01); C09K 11/06 (2006.01); C12Q 1/66 (2006.01);
U.S. Cl.
CPC ...
C09K 11/06 (2013.01); A61K 31/4985 (2013.01); A61K 31/53 (2013.01); C07D 253/075 (2013.01); C07D 487/04 (2013.01); C12Q 1/66 (2013.01); C09K 2211/1007 (2013.01); C09K 2211/1044 (2013.01);
Abstract

Disclosed herein are compositions and methods for stabilizing a luminogenic substrate such as coelenterazine or a functional analog thereof. The functional analog may be furimazine. The composition may include the luminogenic substrate, a thionucleoside, and an organic solvent, in which the thionucleoside is present in an amount effective to stabilize the luminogenic composition against decomposition. The method provided herein stabilizes the luminogenic substrate against decomposition by contacting the luminogenic substrate with an effective amount of the thionucleoside in the presence of the organic solvent. Also provided herein is a kit containing the composition.


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