The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2017
Filed:
Feb. 10, 2015
Applicant:
Merck Patent Gmbh, Darmstadt, DE;
Inventor:
Kin-Ming Lo, Lexington, MA (US);
Assignee:
Merck Patent GmbH, Darmstadt, DE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 14/71 (2006.01); C07K 14/495 (2006.01); A61K 38/17 (2006.01); A61K 39/395 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2896 (2013.01); A61K 38/177 (2013.01); A61K 39/3955 (2013.01); C07K 14/495 (2013.01); C07K 14/71 (2013.01); C07K 16/2827 (2013.01); C07K 16/2863 (2013.01); C07K 16/2866 (2013.01); A61K 2039/505 (2013.01); C07K 2319/00 (2013.01); C07K 2319/33 (2013.01);
Abstract
This invention relates generally to bifunctional molecules including (a) a TGFβRII or fragment thereof capable of binding TGFβ and (b) an antibody, or antigen binding fragment thereof, that binds to an immune checkpoint protein, such as Programmed Death Ligand 1 (PD-L1), uses of such molecules (e.g., for treating cancer), and methods of making such molecules.