The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2017
Filed:
Aug. 15, 2012
Linda Liu, Clarksville, MD (US);
Shannon Marshall, Baltimore, MD (US);
Solomon Langermann, Baltimore, MD (US);
Linda Liu, Clarksville, MD (US);
Shannon Marshall, Baltimore, MD (US);
Solomon Langermann, Baltimore, MD (US);
MedImmune, LLC, Gaithersburg, MD (US);
Abstract
The present invention relates to antibodies (including anti-B7-H4 antibodies) and their antigen-binding fragments and to other molecules (including fusion proteins that bind to the cognate antigen/receptor, etc.) that are capable of immunospecifically binding to B7-H4 and the uses of such molecules in the diagnosis and the treatment of cancer and other diseases. The invention particularly concerns the use of such molecules to retard or prevent tumor growth, inhibit tumor-mediated suppression, eliminate tumors and/or deplete or block the activity of tumor associated macrophages ('TAMs') so as to alter their activity and/or decrease TAM—mediated immune suppression.