The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2017
Filed:
Jul. 23, 2014
Applicant:
Industriale Chimica S.r.l., Milan, IT;
Inventors:
Roberto Lenna, San Giorgio su Legnano, IT;
Riccardo Di Brisco, Trecate, IT;
Assignee:
INDUSTRIALE CHIMICA S.R.L., Milan, IT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07J 1/00 (2006.01); C07J 43/00 (2006.01); C07J 31/00 (2006.01);
U.S. Cl.
CPC ...
C07J 43/003 (2013.01); C07J 31/006 (2013.01);
Abstract
The present invention relates to a novel process for the synthesis of abiraterone and in particular abiraterone acetate, a compound of formula (I) reported below: having pharmacological activity suitable for slowing down the progression of advanced stage prostate cancer. The process is characterized by the fact that the intermediate triflation step is carried out on prasterone (DHEA) or its 3-acetate using Ar—N(OTf)as the triflation reagent, but where Ar is not phenyl, and by the fact that the base used in this step is an alkali metal alcoholate.