The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2017
Filed:
Dec. 21, 2015
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventors:
Urs Schwitter, Basel, CH;
Fritz Bliss, Basel, CH;
Michael Kammerer, Basel, CH;
Florence Tixeront, Basel, CH;
Assignee:
Hoffmann-LaRoche Inc., Little Falls, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 513/04 (2006.01); C07C 55/12 (2006.01); C07C 55/08 (2006.01); C07C 57/15 (2006.01); C07C 55/14 (2006.01); C07C 59/06 (2006.01); C07C 59/185 (2006.01);
U.S. Cl.
CPC ...
C07D 513/04 (2013.01); C07C 55/08 (2013.01); C07C 55/12 (2013.01); C07C 55/14 (2013.01); C07C 57/15 (2013.01); C07C 59/06 (2013.01); C07C 59/185 (2013.01);
Abstract
Co-crystals of Formula I compounds and their pharmaceutical compositions are novel therapeutics for the treatment of diseases, such as human immunodeficiency virus (HIV) infection, hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection and cancer. The co-crystal are more stable to oxidation and aqueous degradation, have a better pharmacokinetic profile and superior biological activity than the corresponding tosylate salt form of Formula I compound.