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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9676768 B1

PDFFull Text
Date of Patent:
Jun. 13, 2017

Filed:

Mar. 20, 2015

Bicyclic heterocycle compounds and their uses in therapy

Applicant:

Astex Therapeutics Limited, Cambridge, GB;

Inventors:

Alison Jo-Anne Woolford, Cambridge, GB;

Steven Howard, Cambridge, GB;

Ildiko Maria Buck, London, GB;

Gianni Chessari, Cambridge, GB;

Christopher Norbert Johnson, Saffron Walden, GB;

Emiliano Tamanini, Cambridge, GB;

James Edward Harvey Day, Cambridge, GB;

Elisabetta Chiarparin, Cambridge, GB;

Thomas Daniel Heightman, Harpenden, GB;

Martyn Frederickson, Cambridge, GB;

Charlotte Mary Griffiths-Jones, Cambridge, GB;

Assignee:

ASTEX THERAPEUTICS LIMITED, Cambridge, GB;

Attorney:

Heslin Rothenberg Farley & Mesiti P.C.

Primary Examiner:

My-Chau T Tran

Int. Cl.
CPC ...
A61K 31/497 (2006.01); A61K 31/501 (2006.01); C07D 403/04 (2006.01); C07D 419/00 (2006.01); C07D 471/04 (2006.01); C07D 401/06 (2006.01); C07D 471/10 (2006.01); C07D 403/06 (2006.01); C07D 487/10 (2006.01); C07D 403/14 (2006.01); A61K 31/496 (2006.01); A61K 31/5025 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); C07D 413/14 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/496 (2013.01); A61K 31/497 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/5025 (2013.01); A61K 31/5377 (2013.01); C07D 401/06 (2013.01); C07D 403/06 (2013.01); C07D 403/14 (2013.01); C07D 413/14 (2013.01); C07D 471/10 (2013.01); C07D 487/04 (2013.01); C07D 487/10 (2013.01); C07D 519/00 (2013.01);
Abstract

The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R, R, R, R, R, R, R, R, R, R, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

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