The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2017
Filed:
Feb. 06, 2015
Applicant:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Inventors:
Santhosh F. Neelamkavil, Edison, NJ (US);
Scott D. Edmondson, Clark, NJ (US);
Zhuyan Guo, Scotch Plains, NJ (US);
Alan W. Hruza, Hackettstown, NJ (US);
Zahid Hussain, Dayton, NJ (US);
Remond Moningka, Jersey City, NJ (US);
Nancy Jo Kevin, East Brunswick, NJ (US);
Assignee:
Merck Sharp & Dohme Corp, Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 217/24 (2006.01); C07D 401/06 (2006.01); C07D 209/46 (2006.01); C07C 55/32 (2006.01); C07D 409/14 (2006.01); C07D 401/12 (2006.01); C07D 417/12 (2006.01); C07D 401/14 (2006.01); C07D 413/12 (2006.01); C07D 405/12 (2006.01);
U.S. Cl.
CPC ...
C07D 217/24 (2013.01); C07C 55/32 (2013.01); C07D 209/46 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 409/14 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01);
Abstract
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.