The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 13, 2017

Filed:

Jan. 09, 2013
Applicants:

Intrexon Corporation, Blacksburg, VA (US);

University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);

Inventors:

J. Mark Braughler, Pittsburgh, PA (US);

Prasanna Kumar, Collegeville, PA (US);

Walter J Storkus, Glenshaw, PA (US);

Hideho Okada, Pittsburgh, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07H 21/04 (2006.01); A61K 35/15 (2015.01); A61K 31/00 (2006.01); A61K 31/166 (2006.01); A61K 31/4245 (2006.01); A61K 45/06 (2006.01); C07K 14/54 (2006.01); C12N 5/0784 (2010.01); G01N 33/68 (2006.01); A01K 67/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/15 (2013.01); A61K 31/00 (2013.01); A61K 31/166 (2013.01); A61K 31/4245 (2013.01); A61K 45/06 (2013.01); C07K 14/5434 (2013.01); C12N 5/0639 (2013.01); G01N 33/6866 (2013.01); A61K 38/00 (2013.01); C07K 2319/715 (2013.01); C12N 2501/23 (2013.01); C12N 2501/24 (2013.01); C12N 2510/00 (2013.01); C12N 2710/10343 (2013.01); C12N 2830/002 (2013.01); C12N 2840/203 (2013.01); G01N 2333/57 (2013.01); G01N 2800/52 (2013.01);
Abstract

This invention provides the field of therapeutics. Most specifically present invention provides methods of generating in vitro engineered dendritic cells conditionally expressing interleukin-12 (IL-12) under the control of a gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals including human.


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