The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 13, 2017

Filed:

Aug. 07, 2012
Applicants:

Xingguo Cheng, San Antonio, TX (US);

Qingwen NI, San Antonio, TX (US);

Thomas B. Potter, Sugar Land, TX (US);

Inventors:

Xingguo Cheng, San Antonio, TX (US);

Qingwen Ni, San Antonio, TX (US);

Thomas B. Potter, Sugar Land, TX (US);

Assignee:

SOUTHWEST RESEARCH INSTITUTE, San Antonio, TX (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 33/42 (2006.01); A61K 49/18 (2006.01); A61N 1/40 (2006.01); B82Y 5/00 (2011.01);
U.S. Cl.
CPC ...
A61K 33/42 (2013.01); A61K 49/1818 (2013.01); A61N 1/403 (2013.01); B82Y 5/00 (2013.01);
Abstract

Magnetic calcium phosphate particles are provided including particles comprising iron oxide and calcium phosphate. A chitosan coating is present on the particles, wherein the particles are less than or equal to 1,000 nm, are magnetic and exhibit a positive charge in the range of 1 mVolts to 60 mVolts. The particles are provided by preparing a calcium hydroxide solution and filtering the calcium hydroxide solution in a membrane filter. An iron chloride solution is formed and combined with the filtered calcium hydroxide solution. In addition, the phosphoric acid solution is combined with the combined solutions of iron chloride and calcium hydroxide, forming a mixture including particles comprising iron oxide and calcium phosphate.


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