The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2017
Filed:
Aug. 30, 2012
Christine Fritsch, Steinbach, FR;
Xizhong Huang, Southborough, MA (US);
Markus Boehm, Rheinfelden, DE;
Emmanuelle Di Tomaso, Lexington, MA (US);
Jan Cosaert, Wommelgem, BE;
Christine Fritsch, Steinbach, FR;
Xizhong Huang, Southborough, MA (US);
Markus Boehm, Rheinfelden, DE;
Emmanuelle di Tomaso, Lexington, MA (US);
Jan Cosaert, Wommelgem, BE;
Novartis AG, Basel, CH;
Abstract
A pharmaceutical combination comprising (a) the phosphatidylinositol 3-kinase (PI3K) inhibitor compound (S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]thiazol-2-yl}-amide) or a pharmaceutically acceptable salt thereof, and (b) at least one mitogen activated protein kinase (MEK) inhibitor or a pharmaceutically acceptable salt, and optionally at least one pharmaceutically acceptable carrier, for simultaneous, separate or sequential administration; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.