The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2017
Filed:
Jun. 09, 2015
Inserm (Institut National DE LA Santé ET DE LA Recherche Médicale), Paris, FR;
Fondation Imagine, Paris, FR;
Assistance Publique-hôpitaux DE Paris (Aphp), Paris, FR;
Université Paris Descartes, Paris, FR;
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Olivier Hermine, Paris, FR;
Flavia Guillem, Paris, FR;
Jean-Benoit Arlet, Paris, FR;
Genevève Courtois, Paris, FR;
Michaela Fontenay, Paris, FR;
Institut National de la Sante et de la Recherche Medicale (INSERM), Paris, FR;
Fondation Imagine, Paris, FR;
Assistance Publique-Hopitaux de Paris (APHP), Paris, FR;
Universite Paris Descartes, Paris, FR;
Centre National de la Recherche Scientifique (CNRS), Paris, FR;
Abstract
The present invention provides methods and pharmaceutical compositions designed to intervene in this defective process and to promote or restore erythrocyte maturation in individuals suffering from a myelodysplastic syndrome. The methods involve maintaining the activity of GATA-1 by preventing sequestration of Hsp70 in the cytoplasm. Accordingly, it is an object of this invention to provide methods of restoring or increasing erythrocyte maturation in a subject suffering from a myelodysplastic syndrome by preventing proteolytic inactivation of GATA-1. In some embodiments, preventing is achieved by administering to the subject a compound that inhibits the XPO1 nuclear transporter.