The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 13, 2017

Filed:

Mar. 11, 2015
Applicant:

Redhill Biopharma Ltd., Tel-Aviv, IL;

Inventors:

Reza Fathi, Oradell, NJ (US);

Gilead Raday, Palo Alto, CA (US);

Guy Goldberg, Tel-Aviv, IL;

Assignee:

RedHill Biopharma Ltd., Tel-Aviv, IL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/24 (2006.01); A61K 31/4178 (2006.01); A61P 1/08 (2006.01); A61P 1/12 (2006.01); A61K 9/20 (2006.01); A61K 9/28 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4178 (2013.01); A61K 9/209 (2013.01); A61K 9/2054 (2013.01); A61K 9/2886 (2013.01);
Abstract

A method of treating a patient comprises orally administering a solid oral dosage form comprising a core comprising a non-ionic polymer matrix, a first amount of ondansetron dispersed within the matrix, and a salt dispersed within the matrix, wherein the first amount of ondansetron ranges from about 9 mg to about 28 mg; a first seal coat surrounding the core, wherein the first seal coat is comprised of a non-ionic polymer matrix; and an immediate release drug layer surrounding the first seal coat and comprising a non-ionic polymer and a second amount of ondansetron dispersed therein, wherein the second amount of ondansetron ranges from about 3 mg to about 8 mg, wherein release of ondansetron from the solid oral dosage form provides exposure to ondansetron for a minimum period of 16 hours so as to result in a reduction in frequency of vomiting, nausea, diarrhea, or a combination thereof.


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