The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 06, 2017

Filed:

Nov. 13, 2013
Applicant:

Protobios, Llc, Tallinn, EE;

Inventors:

Lagle Kasak, Tallinn, EE;

Anri Kivil, Tallinn, EE;

Ave Kris Lend, Tallinn, EE;

Toomas Neuman, Tallinn, EE;

Kaia Palm, Tallinn, EE;

Arno Pihlak, Tallinn, EE;

Anti Alman, Tartu, EE;

Mari-Liis Kruup, Tartu, EE;

Meelis Kull, Bristol, GB;

Balaji Rajashekar, Tartu, EE;

Sulev Reisberg, Tartu, EE;

Martin Sauk, Tartu, EE;

Gerli Viikmaa, Tartu, EE;

Jaak Vilo, Tartu, EE;

Anastassia Kolde, Tartu, EE;

Assignee:

PROTOBIOS, LLC, Tallinn, EE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G06F 19/18 (2011.01); C12N 15/10 (2006.01);
U.S. Cl.
CPC ...
G06F 19/18 (2013.01); C12N 15/1072 (2013.01);
Abstract

A method of forming a metadatabase of minimal epitope profiles including: performing antibody activity profiling from an immunoglobulin fraction of a plurality of samples to form a data set of peptide profiles for each sample, comparing peptide profiles across different samples, assigning a diagnosis or disorder to differentially expressed meta-profiles, constructing a meta-database containing minimal epitope clusters, constructing a database of peptide frequencies, aligning peptides to define the sequence of minimal epitope, verifying the minimal epitope by harboring a connected identifier, providing an enriched affinity sample, and providing a source data for metadatabase a database underlying it.


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