The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2017
Filed:
Aug. 03, 2012
Jeffrey Huff, Lincolnshire, IL (US);
Graham Davis, Princeton, NJ (US);
Mark Hayden, Ingleside, IL (US);
David J. Ecker, Encinitas, CA (US);
Dan Wang, Ottawa, CA;
Gordon Bruce Collier, Fitzroy Harbour, CA;
Jeffrey Huff, Lincolnshire, IL (US);
Graham Davis, Princeton, NJ (US);
Mark Hayden, Ingleside, IL (US);
David J. Ecker, Encinitas, CA (US);
Dan Wang, Ottawa, CA;
Gordon Bruce Collier, Fitzroy Harbour, CA;
IBIS BIOSCIENCES, INC., Carlsbad, CA (US);
Abstract
Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to devices, methods, and systems for sequencing-by-synthesis using changes in pH to monitor base addition. In some embodiments the electrochemical hydrogen ion sensor is a microfabricated mixed metal oxide electrode and in some embodiments the electrochemical hydrogen ion sensor is a membrane electrode. Moreover, in some embodiments the device further comprises a reference electrode. Performing the sequencing reaction involves moving solutions and other fluids (e.g., samples, nucleotide solutions, wash solutions) into and out of the reaction vessel. Thus, in some embodiments, the device further comprises a tube or other transport mechanism or pathway attached to the reaction vessel.