The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 06, 2017

Filed:

Apr. 27, 2012
Applicants:

Ruchika Srivastava, Bangalore, IN;

Sneha Lakshmandas Hemdev, Bangalore, IN;

Ankur Bhatnagar, Bangalore, IN;

Saravanan Desan, Bangalore, IN;

Anuj Goel, Bangalore, IN;

Harish Iyer, Bangalore, IN;

Vana Raja, Hosur, IN;

Lavanya Rao, Bangalore, IN;

Inventors:

Ruchika Srivastava, Bangalore, IN;

Sneha Lakshmandas Hemdev, Bangalore, IN;

Ankur Bhatnagar, Bangalore, IN;

Saravanan Desan, Bangalore, IN;

Anuj Goel, Bangalore, IN;

Harish Iyer, Bangalore, IN;

Vana Raja, Hosur, IN;

Lavanya Rao, Bangalore, IN;

Assignee:

Biocon Limited, Bangalore, IN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/00 (2006.01); C07K 16/28 (2006.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
C12P 21/00 (2013.01); C07K 16/2863 (2013.01); C07K 16/2866 (2013.01); C07K 16/2896 (2013.01); C12N 5/0018 (2013.01); C12N 2500/10 (2013.01);
Abstract

The present disclosure relates to methods of decreasing lactate production in cell culture using divalent transitional metallic salts. The present disclosure also relates to a method of producing polypeptide by adding divalent transitional metallic salt to the cell culture medium for reducing lactate accumulation followed by fermenting and recovering the polypeptide.


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