The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 06, 2017

Filed:

Jan. 22, 2014
Applicant:

Henry Ford Health System, Detroit, MI (US);

Inventors:

Xianshuang Liu, Troy, MI (US);

Zhenggang Zhang, Troy, MI (US);

Michael Chopp, Southfield, MI (US);

Lei Wang, Troy, MI (US);

Assignee:

Henry Ford Health System, Detroit, MI (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 38/17 (2006.01); A61K 38/22 (2006.01); A61K 31/7105 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/7105 (2013.01); A61K 38/1703 (2013.01); A61K 38/2292 (2013.01); C12N 2310/141 (2013.01); C12N 2320/30 (2013.01);
Abstract

Some embodiments comprise methods, systems, and compositions to promote, improve and/or increase neuronal differentiation, oligodendrocyte differentiation, or neurological outcome or function in a patient in need thereof. Some embodiments also comprise the administration a composition comprising a pharmaceutically effective amount of one or more of a group comprising microRNA-146a, a promoter of microRNA-146a expression, a microRNA-146a mimic, thymosin beta 4, and a phosphodiesterase 5 inhibitor to treat neurological conditions, disease, or injury in mammals, including in human beings.


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