The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 06, 2017

Filed:

Jan. 28, 2014
Applicant:

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);

Inventors:

Chandan Das, Little Rock, AR (US);

Ashley A. Jaeger, North Bethesda, MD (US);

Thomas J. Pohida, Monrovia, MD (US);

Michael M. Gottesman, Bethesda, MD (US);

Randall H. Pursley, Gaithersburg, MD (US);

Philip G. McQueen, Silver Spring, MD (US);

Nicole Y. Morgan, Bethesda, MD (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01N 1/02 (2006.01); C12M 1/12 (2006.01); B29D 99/00 (2010.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
C12M 25/02 (2013.01); B29D 99/005 (2013.01); C12N 5/0068 (2013.01); C12N 2533/30 (2013.01);
Abstract

The present disclosure is directed to embodiments of microstructured membranes, methods of fabricating microstructured membranes, bioreactors housing microstructured membranes, and methods of using bioreactors and microstructured membranes. In some embodiments, the present disclosure allows culturing of cellular tissues in an environment which more accurately resembles a native environment. In some more specific embodiments, the present disclosure allows culturing of tumor cells on a membrane having a microfabricated pattern which mimics a native vasculature system.


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