The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2017
Filed:
Apr. 25, 2014
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Renyu Liu, Media, PA (US);
Jeffery G Saven, Philadelphia, PA (US);
Jose Manuel Perez-Aguilar, New York, NY (US);
Felipe Matsunaga, Olmsted Township, OH (US);
Jin Xi, Media, PA (US);
The Trustees Of The University Of Pennsylvania, Philadelphia, PA (US);
Abstract
Described herein are recombinant integral membrane proteins having multiple transmembrane domains that have been engineered to be less hydrophobic, through alteration of the amino acid sequence of the native protein, but retain the ability to bind their natural ligand. The decreased hydrophobicity of the described proteins makes them more water soluble than the native protein, which allows the described proteins to be expressed in bacteria in large quantities and isolated in the absence of membranes, all while retaining the ability to interact with known ligands.