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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9670258 B1

PDFFull Text
Date of Patent:
Jun. 06, 2017

Filed:

Aug. 18, 2016

Positive modulator of bone morphogenic protein-2

Applicants:

Ferring B.v., Hoofddorp, NL;

Brookhaven Science Associates, Llc, Upton, NY (US);

Inventors:

Paul O. Zamora, Gaithersburg, MD (US);

Louis A. Pena, Poquott, NY (US);

Xinhua Lin, Plainview, NY (US);

Takahashi Kazuyuki, Germantown, MD (US);

Assignees:

Ferring B.V., Hoofddorp, NL;

Brookhaven Science Associates, LLC, Upton, NY (US);

Attorney:

Dechert LLP

Primary Examiner:

Xiaozhen Xie

Int. Cl.
CPC ...
A61K 38/18 (2006.01); C07K 14/47 (2006.01); C07K 14/51 (2006.01); A61K 31/727 (2006.01); A61K 47/48 (2006.01); A61P 19/02 (2006.01); C07K 14/475 (2006.01); A61L 27/34 (2006.01); C07H 21/04 (2006.01); C07K 14/50 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4705 (2013.01); A61K 31/727 (2013.01); A61K 38/1875 (2013.01); A61K 47/48246 (2013.01); A61L 27/34 (2013.01); C07H 21/04 (2013.01); C07K 14/475 (2013.01); C07K 14/503 (2013.01); C07K 14/51 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01);
Abstract

Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.

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