The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 06, 2017

Filed:

Feb. 18, 2014
Applicant:

Savid Therapeutics Inc., Tokyo, JP;

Inventors:

Akira Sugiyama, Tokyo, JP;

Hirofumi Doi, Chiba, JP;

Tatsuhiko Kodama, Tokyo, JP;

Tsuyoshi Inoue, Osaka, JP;

Eiichi Mizohata, Osaka, JP;

Tatsuya Kawato, Tokushima, JP;

Tomohiro Meshizuka, Osaka, JP;

Motomu Kanai, Tokyo, JP;

Yohei Shimizu, Tokyo, JP;

Tomohiro Yamamoto, Tokyo, JP;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/36 (2006.01); C07D 495/04 (2006.01); C07D 497/04 (2006.01); C07D 498/04 (2006.01); G01N 33/543 (2006.01);
U.S. Cl.
CPC ...
C07K 14/36 (2013.01); C07D 495/04 (2013.01); C07D 497/04 (2013.01); C07D 498/04 (2013.01); G01N 33/54306 (2013.01); G01N 2333/36 (2013.01);
Abstract

It is an object of the present invention to provide a mutant streptavidin with a reduced affinity for natural biotin, and also to provide a modified biotin having a high affinity for the mutant streptavidin with a reduced affinity for natural biotin. According to the present invention, there is provided a reagent kit for use in treatments or diagnoses, which comprises: (a) a mutant streptavidin with a reduced affinity for natural biotin or biocytin; and a modified biotin having a high affinity for the above-described mutant streptavidin.


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