The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2017
Filed:
Dec. 02, 2004
Luis Sobral, Loures, PT;
Dionisio Martin, Salamanca, ES;
William Heggie, Palmela, PT;
Emilia Leitäo, Säo Marcos, PT;
Luis Sobral, Loures, PT;
Dionisio Martin, Salamanca, ES;
William Heggie, Palmela, PT;
Emilia Leitäo, Säo Marcos, PT;
Hovione Inter Ltd., Lucerne, CH;
Abstract
A process for preparing compounds of formula [II] by esterification of the C-17 hydroxyl group of 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid, the compound of formula [I] comprises treating compound [I] with a slight excess of an acyl chloride of general formula R—COCl, where R represents —CH2CH3, —CH2CH2CH3 or —CH(CH3)2, in an inert solvent, in the presence of a tertiary amine. Preferably the process is carried out using pyridine in the presence of acetone at a temperature of from 5° C. to −20° C.