The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2017
Filed:
Sep. 07, 2016
Astellas Pharma Inc., Chuo-ku, JP;
Yohei Koganemaru, Tokyo, JP;
Satoshi Miyamoto, Tokyo, JP;
Shinya Nagashima, Tokyo, JP;
Akio Kamikawa, Tokyo, JP;
Koichi Yonezawa, Tokyo, JP;
Yuka Koizumi, Tokyo, JP;
Satoshi Aoki, Tokyo, JP;
Takashi Ogiyama, Tokyo, JP;
Shimpei Kawakami, Tokyo, JP;
Shigeki Kunikawa, Tokyo, JP;
Ryo Sato, Tokyo, JP;
Junichi Shishikura, Tokyo, JP;
Shuichirou Kakimoto, Tokyo, JP;
Hiroshi Yamada, Tokyo, JP;
Keisuke Tamaki, Tokyo, JP;
Astellas Pharma Inc., Chuo-ku, JP;
Abstract
[Problem] Provided is a compound having a positive allosteric modulating activity (PAM activity) on an α7 nicotinic acetylcholine receptor (α7 nACh receptor). [Means for Solution] The present inventors have studied on a PAM activity on an α7 nACh receptor, and they have found that a tetrahydrooxepinopyridine compound has a PAM activity on an α7 nACh receptor, thereby completing the present invention. The tetrahydrooxepinopyridine compound of the present invention has a PAM activity on an α7 nACh receptor and can be expected as an agent for preventing or treating dementia, cognitive impairment, schizophrenia, Alzheimer's disease, CIAS, negative symptoms of schizophrenia, inflammatory diseases, or pain.