The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 06, 2017

Filed:

Sep. 17, 2014
Applicants:

Calitor Sciences, Llc, Newbury Park, CA (US);

Sunshine Lake Pharma Co., Ltd., Dongguan, Guangdong, CN;

Inventors:

Ning Xi, Newbury Park, CA (US);

Liang Wang, Guangdong, CN;

Zuping Wu, Guangdong, CN;

Xuejin Feng, Guangdong, CN;

Yanjun Wu, Guangdong, CN;

Assignees:

CALITOR SCIENCES, LLC, Newbury Park, CA (US);

SUNSHINE LAKE PHARMA CO., LTD., Dongguan, Guangdong, CN;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/54 (2006.01); C07D 401/00 (2006.01); C07D 403/00 (2006.01); C07D 413/14 (2006.01); C07D 401/14 (2006.01); A61K 31/517 (2006.01); C07D 403/14 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 413/14 (2013.01); A61K 31/517 (2013.01); A61K 45/06 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01);
Abstract

The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not limited to leukemias and solid tumors, in mammals, especially humans.


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