The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2017
Filed:
Mar. 13, 2013
Applicants:
University Court of the University of Dundee, Dundee, GB;
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Inventors:
Philip Cohen, Dundee, GB;
Kristopher Clark, Dundee, GB;
Hwan Geun Choi, Chestnut Hill, MA (US);
Nathanael Gray, Boston, MA (US);
Assignees:
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
University Court of the University of Dundee, Dundee, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 239/48 (2006.01); C07D 403/12 (2006.01); A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/5377 (2006.01); C07D 413/12 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 239/48 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); C07D 403/12 (2013.01); C07D 413/12 (2013.01); C07D 487/04 (2013.01);
Abstract
The present invention relates to the discovery that salt inducible kinases (SIKs) suppress the formation of anti-inflammatory molecules such as IL-10, which are important for the resolution of inflammation and identifies SIK inhibitors that may be used to treat disorders associated with undesirable inflammation, such as inflammatory bowel disease and/or autoimmune disorders.