The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 06, 2017

Filed:

Jul. 11, 2014
Applicant:

Siga Technologies, Inc., Corvallis, OR (US);

Inventors:

Shanthakumar R. Tyavanagimatt, Corvallis, OR (US);

N K Peter Samuel, Corvallis, OR (US);

Joseph Paz, Corvallis, OR (US);

Ying Tan, Walnut Creek, CA (US);

Dennis E. Hruby, Albany, OR (US);

Assignee:

SIGA TECHNOLOGIES, INC., Corvallis, OR (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 209/70 (2006.01); C07D 209/76 (2006.01); A61K 47/38 (2006.01); A61K 9/16 (2006.01); A61K 31/4035 (2006.01);
U.S. Cl.
CPC ...
C07D 209/70 (2013.01); A61K 9/1694 (2013.01); A61K 31/4035 (2013.01); A61K 47/38 (2013.01); C07D 209/76 (2013.01);
Abstract

Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus. Also disclosed are methods for the preparation of amorphous solid dispersion of N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide.


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