The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 06, 2017

Filed:

Oct. 27, 2014
Applicant:

Chongqing Runze Pharmaceutical Company Limited, Chongqing, CN;

Inventor:

Lei Ye, Chongqing, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 207/273 (2006.01); A61K 31/4015 (2006.01);
U.S. Cl.
CPC ...
C07D 207/273 (2013.01); C07B 2200/13 (2013.01);
Abstract

(S)-4-hydroxy-2-oxo-1-pyrrolidine crystal form III (called crystal form III of (S) -oxiracetam for short) has diffraction peaks at diffraction angles 2θ, wherein the diffraction angles 2θ are equal to 10.54, 13.70, 14.44, 15.60, 17.12, 18.88, 19.24, 20.66, 20.84, 21.18, 21.82, 22.94, 23.24, 24.88, 27.20, 27.48, 28.24, 30.46, 30.80, 31.52, 32.00, 32.34, 32.90, 33.20, 34.40, 34.62, 37.30, 37.50, 38.28, 38.96, and 40.02°. The (S)-oxiracetam crystal form III of the present invention has an obvious effect on memory dysfunction, is dissolved in water fast, has high bioavailability, and can be used to prepare various pharmaceutical compositions. The (S)-oxiracetam crystal form III obtained by using the preparation method of the present invention is high in purity. The preparation method of the present invention is performed in a mild condition, is easy in operation, introduces less impurities, has desirable reproducibility, is easily controlled during production, and is applicable to industrial production.


Find Patent Forward Citations

Ye, Lei. (2017). Crystal form iii of (s)-oxiracetam, preparation method and use thereof (U.S. Patent No. 9670156). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9670156

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