The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 06, 2017

Filed:

Jul. 30, 2015
Applicant:

Proton Innovations, Llc, Rochester, NY (US);

Inventor:

James A. Bonafini, Jr., Kendall, NY (US);

Assignee:

Proton Innovations, LLC, Rochester, NY (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61L 29/06 (2006.01); A61L 29/16 (2006.01); C08G 18/63 (2006.01); C08G 18/65 (2006.01); C08G 18/76 (2006.01); C08G 18/32 (2006.01); A61M 25/00 (2006.01);
U.S. Cl.
CPC ...
A61L 29/06 (2013.01); A61L 29/16 (2013.01); C08G 18/3206 (2013.01); C08G 18/638 (2013.01); C08G 18/6564 (2013.01); C08G 18/7671 (2013.01); A61L 2300/404 (2013.01); A61M 25/0017 (2013.01);
Abstract

A method of preparing a mixed-phase thermoplastic biomaterial comprises contacting and reacting a diol and a graft pre-polymer comprising a diol and at least one covalently bonded unsaturated monomer with an organic diisocyanate compound. The reaction is conducted within an aprotic solvent and for a period of time and at a temperature sufficient to produce the mixed-phase thermoplastic biomaterial. The diol may be selected from the group consisting of siloxane diols, polyether diols, polyester diols and polycarbonate diols while the at least one covalently bonded unsaturated monomer may be selected from the group consisting of a fluorinated monomer, a siloxane monomer, an aliphatic ester of methacrylic acid, a cyclic ester of methacrylic acid, a charged monomer, a sulfonium salt, a vinyl monomer with phenol or benzoic acid, N-vinyl pyrrolidone, an aminoglucoside, and a therapeutic agent. The mixed-phase thermoplastic biomaterial may further include an anti-microbial, a therapeutic agent or both.


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