The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2017
Filed:
Nov. 20, 2013
Applicant:
The J. David Gladstone Institutes, San Francisco, CA (US);
Inventors:
Katerina Akassoglou, San Francisco, CA (US);
Jae Kyu Ryu, San Francisco, CA (US);
Assignee:
THE J. DAVID GLADSTONE INSTITUTES, San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/00 (2006.01); A61K 49/00 (2006.01); C07K 14/75 (2006.01); A01K 67/027 (2006.01);
U.S. Cl.
CPC ...
A61K 49/0008 (2013.01); A01K 67/027 (2013.01); C07K 14/75 (2013.01); A01K 2207/10 (2013.01); A01K 2227/105 (2013.01); A01K 2267/035 (2013.01); A01K 2267/0318 (2013.01);
Abstract
The present invention provides non-human animal models of neuronal injury and/or cognitive dysfunction and methods of making and using such animal models. The animal models of the invention are particularly suited to assessing neurodegeneration in selected regions of interest in the CNS, and thus especially useful for testing the therapeutic efficacy of agents targeting neurodegeneration associated with aging, neurodegenerative diseases, autoimmunity and trauma (e.g., ischemia).