The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2017
Filed:
Nov. 18, 2013
Zorica Dragic, Basel, CH;
Sabine Geisse, Weil am Rhein, DE;
Rita Schmitz, Saint-Marcet, FR;
Burkhard Wilms, Weil am Rhein, DE;
Zorica Dragic, Basel, CH;
Sabine Geisse, Weil am Rhein, DE;
Rita Schmitz, Saint-Marcet, FR;
Burkhard Wilms, Weil am Rhein, DE;
NOVARTIS AG, Basel, CH;
Abstract
The present invention is based on the finding that the combination of a specific 5'UTR polynucleotide sequence (see SEQ ID NO 1) and the hCD33 secretory leader sequence in an expression cassette for expressing a polypeptide of interest results in a surprisingly better expression level of the polypeptide of interest compared to prior art expression cassettes. Based on this finding, the present invention inter alia provides novel expression cassettes, expression vectors and methods for producing a polypeptide of interest with high yield.