The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 30, 2017

Filed:

Mar. 11, 2014
Applicant:

Dainippon Sumitomo Pharma Co., Ltd., Osaka-shi, Osaka, JP;

Inventors:

Tomomi Nakatani, Ibaraki, JP;

Koichi Saito, Ibaraki, JP;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 7/08 (2006.01); C07K 7/06 (2006.01); C07K 14/47 (2006.01); A61K 9/00 (2006.01); A61K 47/12 (2006.01); A61K 39/00 (2006.01); C07K 7/00 (2006.01); A61K 38/00 (2006.01); A61K 9/08 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4748 (2013.01); A61K 9/0019 (2013.01); A61K 39/0011 (2013.01); A61K 47/12 (2013.01); A23V 2200/308 (2013.01); A61K 9/08 (2013.01); A61K 38/00 (2013.01); C07K 7/00 (2013.01);
Abstract

The invention provides an aqueous liquid composition comprising a WT1 protein-derived cancer antigen peptide, wherein the peptide is stabilized. The aqueous liquid composition contains a peptide and an excipient, and has a pH of 3-6. The peptide has the amino acid sequence Arg-Met-Phe-Pro-Asn-Ala-Pro-Tyr-Leu (SEQ ID NO: 1), wherein optionally 1 to 3 amino acids are deleted, substituted and/or added, such that the peptide has a cytotoxic T cell-inducing ability. The excipient is (a) an alpha hydroxyl acid selected from glycolic acid, lactic acid, malic acid, tartaric acid, citric acid and pharmacologically acceptable salts thereof, (b) a dicarboxylic acid selected from malonic acid, succinic acid, glutaric acid, maleic acid and pharmacologically acceptable salts thereof, and/or (c) methionine.


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