The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2017
Filed:
Dec. 27, 2013
Aduro Biotech, Inc., Berkeley, CA (US);
Peter M. Lauer, Albany, CA (US);
William G. Hanson, Walnut Creek, CA (US);
Justin Skoble, Berkeley, CA (US);
Meredith Lai Ling Leong, Oakland, CA (US);
Marcella Fasso, Richmond, CA (US);
Dirk Brockstedt, Richmond, CA (US);
Thomas W. Dubensky, Jr., Piedmont, CA (US);
ADURO BIOTECH, INC., Berkeley, CA (US);
Abstract
The present invention provides nucleic acids, expression systems, and vaccine strains which provide efficient expression and secretion of antigens of interest into the cytosol of host cells, and elicit effective CD4 and CD8 T cell responses by functionally linking Listerial or other bacterial signal peptides/secretion chaperones as N-terminal fusion partners in translational reading frame with selected recombinant encoded protein antigens. These N-terminal fusion partners are deleted (either by actual deletion, by mutation, or by a combination of these approaches) for any PEST sequences native to the sequence, and/or for certain hydrophobic residues.