The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2017
Filed:
Aug. 19, 2015
Pfizer Inc., New York, NY (US);
Andrew Fensome, Harvard, MA (US);
Ariamala Gopalsamy, Lexington, MA (US);
Brian S. Gerstenberger, Brookline, MA (US);
Ivan Viktorovich Efremov, Chestnut Hill, MA (US);
Zhao-Kui Wan, Lexington, MA (US);
Betsy Pierce, East Lyme, CT (US);
Jean-Baptiste Telliez, Lexington, MA (US);
John I. Trujillo, Ledyard, CT (US);
Liying Zhang, Groton, CT (US);
Li Xing, Lexington, MA (US);
Eddine Saiah, Brookline, MA (US);
Pfizer Inc., New York, NY (US);
Abstract
A compound having the structure: or an acceptable salt thereof, wherein X is N or CR, where R is hydrogen, alkyl, etc.; A is selected from the group consisting of a bond, C═O, —SO—, etc.; A' is selected from the group consisting of a bond, C═O, etc.; Z is —(CH)— or a bond, etc.; Rand R′ are independently selected from the group consisting of hydrogen, alkyl, etc.; Ris selected from hydrogen, alkyl, etc.; Ris selected from the group consisting of hydrogen, and amino; Ris monocyclic or bicyclic, etc.; Ris independently selected from hydrogen, alkyl, etc.; h, j, k, m, n and q are integers as defined in the specification. Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations with other therapeutic agents.