The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2017
Filed:
Sep. 25, 2013
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Helga Künzer, Reinsfeld, DE;
Klara Muno, Reinsfeld, DE;
Erich Künzer, Reinsfeld, DE;
Martin Künzer, Aachen, DE;
Christel Bernsdorf, Sylt, DE;
Norbert Schmees, Berlin, DE;
Joachim Kuhnke, Potsdam, DE;
Bernard Haendler, Berlin, DE;
Roland Neuhaus, Berlin, DE;
Pascale Lejeune, Berlin, DE;
Stephan Siegel, Berlin, DE;
Martin Krüger, Berlin, DE;
Amaury Ernesto Fernandez-Montalvan, Berlin, DE;
Hermann Künzer, Berlin, DE;
Daniel Gallenkamp, Wuppertal, DE;
BAYER PHARMA AKTIENGESELLSCHAFT, Berlin, DE;
Abstract
The present invention relates to BET-protein-inhibitory, in particular BRD4-inhibitory 5-aryltriazoloazepines of the general formula (I) in which R, R, Rand Rhave the meanings given for the general formula (I),to pharmaceutical compositions comprising the compounds according to the invention, and to the prophylactic and therapeutic use thereof for hyperproliferative disorders, especially for neoplastic disorders. The present invention further relates to the use of BET protein inhibitors in viral infections, in neurodegenerative disorders, in inflammatory diseases, in atherosclerotic disorders and in male fertility control.