The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 30, 2017

Filed:

Dec. 17, 2015
Applicant:

Myokardia, Inc., South San Francisco, CA (US);

Inventors:

Johan Oslob, Sunnyvale, CA (US);

Danielle Aubele, San Mateo, CA (US);

Marc Evanchik, San Jose, CA (US);

Jonathan Charles Fox, San Francisco, CA (US);

Mark Grillo, San Francisco, CA (US);

Brian Kane, Oakland, CA (US);

Robert McDowell, San Francisco, CA (US);

Yonghong Song, Foster City, CA (US);

Min Zhong, Palo Alto, CA (US);

Assignee:

MYOKARDIA, INC., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61K 31/55 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/519 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); C07D 487/04 (2013.01);
Abstract

The present invention provides novel bicyclic pyrimidinedione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.


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