The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 30, 2017

Filed:

Oct. 14, 2014
Applicant:

Eisai R&d Management Co., Ltd., Tokyo, JP;

Inventors:

Roch Boivin, North Chelmsford, MA (US);

Hans Hansen, Somerville, MA (US);

Sally Ishizaka, Weston, MA (US);

Matthew Mackey, Melrose, MA (US);

Shawn Schiller, Haverhill, MA (US);

Chikako Ogawa, Basel, CH;

Sridhar Narayan, Belmont, MA (US);

Peter Bertinato, Old Lyme, CT (US);

Gregory Berger, East Lyme, CT (US);

Atsushi Endo, Andover, MA (US);

Robert T. Yu, Arlington, MA (US);

Lynn Hawkins, Concord, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/02 (2006.01); C07D 413/14 (2006.01); C07D 471/04 (2006.01); C07D 401/14 (2006.01); C07D 417/14 (2006.01); C07D 401/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/02 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01);
Abstract

Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.


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