The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 30, 2017

Filed:

Jun. 05, 2013
Applicant:

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

Natalia Trayanova, Baltimore, MD (US);

Xiaozhong Chen, Hoover, AL (US);

Assignee:

The Johns Hopkins University, Baltimore, MD (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61B 5/04 (2006.01); A61B 5/0402 (2006.01); A61B 5/0452 (2006.01); A61B 5/0464 (2006.01); A61B 5/0245 (2006.01); A61B 5/0432 (2006.01); A61B 5/0456 (2006.01); A61B 5/0468 (2006.01);
U.S. Cl.
CPC ...
A61B 5/04012 (2013.01); A61B 5/0245 (2013.01); A61B 5/0402 (2013.01); A61B 5/0432 (2013.01); A61B 5/0452 (2013.01); A61B 5/0456 (2013.01); A61B 5/0464 (2013.01); A61B 5/0468 (2013.01);
Abstract

The present invention is directed to a method for determining onset of ventricular arrhythmias using bounded-input bounded-output stability of QT interval (QTI) dynamics. The method of the present invention includes two parts. A first part of the method determines the dependence of each QTI on several prior QTIs and RR intervals (RRI). This determination is represented as an autoregressive model with exogenous input (ARX). A second part of the method determines the BIBO stability of the ARX model in the z-domain. The metrics associated with the first and second parts of the method are then used to predict onset of arrhythmia.


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