The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 23, 2017

Filed:

Jun. 22, 2015
Applicant:

Postech Academy-industry Foundation, Pohang-si, Gyeongsangbuk-do, KR;

Inventors:

Kyo Han Ahn, Pohang-si, KR;

Hyunsoo Moon, Uijeongbu-si, KR;

Dokyoung Kim, Pohang-si, KR;

Ki Hean Kim, Pohang-si, KR;

Hye Gun Ryu, Daegu, KR;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/58 (2006.01); G01N 21/64 (2006.01); C07D 311/92 (2006.01); G01N 33/68 (2006.01); C07D 311/78 (2006.01); C07D 311/94 (2006.01); A61K 49/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/582 (2013.01); A61K 49/0021 (2013.01); C07D 311/78 (2013.01); C07D 311/92 (2013.01); C07D 311/94 (2013.01); G01N 21/6428 (2013.01); G01N 33/6896 (2013.01); G01N 2021/6439 (2013.01); G01N 2333/4709 (2013.01); G01N 2800/2821 (2013.01);
Abstract

Provided are acedan derivatives having an extended π bond, a method for preparing the acedan derivatives, and a method for two-photon microscopy imaging of amyloid-beta plaque using the acedan derivatives; more particularly, to two-photon absorbing fluorescent compounds having a longer absorption wavelength and emission wavelength than acedan and acedan derivatives which are conventional two-photon absorbing fluorophores. The compounds provided may be usefully used for in vivo imaging studies by imaging cells or tissue using the compounds, and may also be usefully used for diagnosing Alzheimer's disease by imaging amyloid-beta plaque using the compounds.


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