The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 23, 2017

Filed:

Jan. 13, 2014
Applicant:

Atrogi Ab, Stockholm, SE;

Inventor:

Tore Bengtsson, Vaxholm, SE;

Assignee:

ATROGI AB, Stockholm, SE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); G01N 33/68 (2006.01); G01N 33/50 (2006.01); A61K 31/137 (2006.01); C07K 14/72 (2006.01); C12Q 1/48 (2006.01); C07K 14/70 (2006.01); C12N 9/12 (2006.01); G01N 33/566 (2006.01); C07K 14/705 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6883 (2013.01); A61K 31/137 (2013.01); C07K 14/70571 (2013.01); C07K 14/723 (2013.01); C12N 9/1205 (2013.01); C12Q 1/485 (2013.01); G01N 33/502 (2013.01); G01N 33/566 (2013.01); G01N 33/6872 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/4703 (2013.01); G01N 2333/726 (2013.01); G01N 2500/00 (2013.01); G01N 2500/10 (2013.01); G01N 2800/04 (2013.01); G01N 2800/042 (2013.01);
Abstract

A method of screening for a candidate compound for the treatment of a condition involving dysregulation of metabolism in a mammal, by bringing a compound into contact with cells that express a GPCR and that further express a GRK, determining whether the contacting causes a response of the GRK in cells brought into contact with the compound, determining whether the contacting causes a response of a classical secondary messenger in cells brought into contact with the compound; and identifying the candidate compound based on the determined GRK response and response of a classical secondary messenger in the cells. A kit for use in the method. A compound for use in the treatment of a condition involving dysregulation of metabolism in a mammal and a method of treatment of such a condition.


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