The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2017
Filed:
May. 18, 2015
Applicant:
Geron Corporation, Menlo Park, CA (US);
Inventors:
Sergei Gryaznov, San Mateo, CA (US);
Krisztina Pongracz, Oakland, CA (US);
Assignee:
Geron Corporation, Menlo Park, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); C07C 233/18 (2006.01); A61K 47/48 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 47/48038 (2013.01); A61K 47/48046 (2013.01); A61K 47/48053 (2013.01); A61K 47/48123 (2013.01); C07C 233/18 (2013.01); C07H 21/02 (2013.01); C07H 21/04 (2013.01); C12N 15/113 (2013.01); C12Y 207/07049 (2013.01); C12N 2310/11 (2013.01); C12N 2310/113 (2013.01); C12N 2310/14 (2013.01); C12N 2310/31 (2013.01); C12N 2310/314 (2013.01); C12N 2310/351 (2013.01); C12N 2310/3515 (2013.01); C12N 2320/30 (2013.01);
Abstract
Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.