The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2017
Filed:
Nov. 02, 2012
Applicant:
Wisconsin Alumni Research Foundation, Madison, WI (US);
Inventors:
Jordan Marshall Sand, Madison, WI (US);
Mark Eric Cook, Madison, WI (US);
Daniel Elmer Butz, Madison, WI (US);
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION, Madison, WI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/40 (2006.01); C12N 9/20 (2006.01); C07K 5/113 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/40 (2013.01); C07K 5/1021 (2013.01); C12N 9/20 (2013.01); C12Y 301/01004 (2013.01); A61K 2039/505 (2013.01); C07K 2317/11 (2013.01); C07K 2317/23 (2013.01); C07K 2317/76 (2013.01);
Abstract
Described herein are peptides from secretory phospholipase A-IB and antibodies that can be used to reduce the contribution of the gastrointestinal tract to inflammatory processes including systemic inflammatory responses. Specifically, antibodies that bind specifically a peptide from secretory phospholipase A-IB prevent death in a mouse model of LPS-induced endotoxemia. The antibodies described herein are particularly useful to treat systemic inflammatory response syndromes, including sepsis.