The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2017
Filed:
Jun. 09, 2014
Novo Nordisk A/s, Bagsvaerd, DK;
Jane Spetzler, Broenshoej, DK;
Lauge Schaeffer, Lyngby, DK;
Jesper Lau, Farum, DK;
Janos T. Kodra, Copenhagen OE, DK;
Kjeld Madsen, Videbaek, DK;
Patrick W. Garibay, Holte, DK;
Jacob Kofoed, Vaerloese, DK;
Steffen Reedtz-Runge, Birkeroed, DK;
Ingrid Pettersson, Frederiksberg, DK;
Novo Nordisk A/S, Bagsvaerd, DK;
Abstract
The invention relates to truncated GLP-1 analogs, in particular a GLP-1 analog which is a modified GLP-1(7-35) (SEQ ID No 1) having: i) a total of 2, 3, 4, 5 6, 7, 8, or 9 amino acid substitutions as compared to GLP-1(7-35), including a) a Glu residue at a position equivalent to position 22 of GLP-1(7-35), and b) an Arg residue at a position equivalent to position 26 of GLP-1(7-35); as well as derivatives thereof, and therapeutic uses and compositions. These analogs and derivatives are highly potent, have a good binding affinity to the GLP-1 receptor, also to the extracellular domain of the GLP-1 receptor, which is of potential relevance achieving long-acting, stable GLP-1 compounds with a potential for once weekly administration.