The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2017
Filed:
Jan. 14, 2015
Applicant:
Cytos Biotechnology Ag, Zürich-Schlieren, CH;
Inventors:
Susanne Richter, Schlieren, CH;
Simon Topell, Zurich, CH;
Assignee:
Kuros Biosciences AG, , CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 7/02 (2006.01); C07K 1/18 (2006.01); C07K 14/005 (2006.01); C07K 1/22 (2006.01); C07K 1/16 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); C07K 1/165 (2013.01); C07K 1/22 (2013.01); C12N 7/00 (2013.01); C12N 2730/10123 (2013.01); C12N 2730/10151 (2013.01); C12N 2795/18123 (2013.01); C12N 2795/18151 (2013.01);
Abstract
The invention provides a process for the purification recombinantly expressed, self-assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first chromatography using an anion exchange matrix, a second chromatography using hydroxyapatite and, optionally, a size exclusion chromatography. VLP preparations obtained by the process of the invention are essentially free of endotoxin contaminations.