The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2017
Filed:
Feb. 13, 2013
Applicant:
Orphagen Pharmaceuticals, San Diego, CA (US);
Inventors:
Scott Thacher, San Diego, CA (US);
Xiaolin Li, San Diego, CA (US);
Robert Babine, Carlsbad, CA (US);
Bruno Tse, San Francisco, CA (US);
Assignee:
ORPHAGEN PHARMACEUTICALS, San Diego, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/58 (2006.01); A01N 41/06 (2006.01); A01N 37/00 (2006.01); C07J 9/00 (2006.01); C07C 311/21 (2006.01); C07D 401/14 (2006.01); C07J 21/00 (2006.01); C07D 249/12 (2006.01); C07D 493/10 (2006.01);
U.S. Cl.
CPC ...
C07J 9/005 (2013.01); A61K 31/58 (2013.01); C07C 311/21 (2013.01); C07D 249/12 (2013.01); C07D 401/14 (2013.01); C07D 493/10 (2013.01); C07J 9/00 (2013.01); C07J 21/00 (2013.01);
Abstract
Methods for modulating (inhibiting or stimulating) retinoid-related orphan receptor γ (RORγ) activity. This modulation has numerous effects, including inhibition of T-17 cell function and/or T-17 cell activity, and inhibition of re-stimulation of T-17 cells, which are beneficial to treatment of inflammation and autoimmune disorders. Stimulation of RORγ results in stimulation of T-17 cell function and/or activity which is beneficial for immune-enhancing compositions (e.g., vaccines).