The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2017
Filed:
Oct. 16, 2014
Tongli Biomedical Co., Ltd., Zhangjiagang, Jiangsu, CN;
Mingxin Qian, Jiangsu, CN;
Rodney JY Ho, Jiangsu, CN;
Chunsheng Qiao, Jiangsu, CN;
Junwei Shi, Jiangsu, CN;
Tongli Biomedical Co., Ltd., , CN;
Abstract
The present invention relates to a crystal form of (R)-praziquantel and a preparation method and uses thereof. The X-ray diffraction pattern (CuKα radiation) of the crystal form of (R)-praziquantel at 25° C. shows the following diffraction peaks: 2-Theta =6.9±0.2°, 8.3±0.2°, 15.1±0.2°, 17.4±0.2°, 19.8±0.2°, 21.9±0.2°, 24.3 ±0.2° or d=12.74±0.20 Å, 10.61±0.20 Å, 5.87±0.20 Å, 5.09±0.20 Å, 4.48±0.20 Å, 4.06±0.20 Å, 3.66±0.20 Å. Compared to the existing crystal form of praziquantel, the crystal form of the present invention has better solubility, better drug efficacy and better pharmacokinetic characteristics. The preparation method of the present invention has the following advantages: good reproducibility, environmentally friendly, low cost, and able to operate at a normal pressure and temperature, and suitable for large-scale production.