The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2017
Filed:
Jun. 03, 2016
Applicant:
Pharmacyclics Llc, Sunnyvale, CA (US);
Inventors:
Wei Chen, Fremont, CA (US);
Zhaozhong J. Jia, San Mateo, CA (US);
William D. Thomas, San Jose, CA (US);
Assignee:
PHARMACYCLICS LLC, Sunnyvale, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 403/04 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); A61K 31/53 (2006.01); A61K 31/497 (2006.01); A61K 31/445 (2006.01); A61K 31/397 (2006.01); A61K 31/4025 (2006.01); C07D 471/04 (2006.01); A61K 31/501 (2006.01); A61P 19/02 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); A61K 31/397 (2013.01); A61K 31/4025 (2013.01); A61K 31/445 (2013.01); A61K 31/497 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01);
Abstract
Disclosed herein are reversible and irreversible inhibitors of Bruton's tyrosine kinase (Btk). Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are described, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.