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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9656987 B1

PDFFull Text
Date of Patent:
May. 23, 2017

Filed:

Mar. 03, 2014

Process for preparing 3-[(s)-7-bromo-2-((2-oxopropyl)amino)-5-pyridin-2-yl-3h-1,4-benzodiazepin-3-yl]propionic acid methyl ester

Applicant:

Paion Uk Limited, Cambridge Cambridgeshire, GB;

Inventors:

Yuji Kawakami, Fukui, JP;

Tatsushi Murase, Fukui, JP;

Daisuke Tanaka, Fukui, JP;

Hideyuki Yoshiyama, Fukui, JP;

Shinitsu Kuwabe, Fukui, JP;

Assignee:

PAION UK LIMITED, , GB;

Attorney:

Foley & Lardner LLP

Primary Examiner:

Douglas M Willis

Int. Cl.
CPC ...
C07D 243/14 (2006.01); C07D 401/04 (2006.01); A61K 31/5517 (2006.01); C07D 487/04 (2006.01); B01J 31/02 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); A61K 31/5517 (2013.01); B01J 31/0235 (2013.01); C07D 487/04 (2013.01); B01J 2231/763 (2013.01);
Abstract

A process for preparing 3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4,-benzodiazepin-3-yl]propionic acid methyl ester at a high conversion rate with good reproducibility by oxidizing 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester in the presence of an oxidation catalyst is provided by defining the ammonium ion content of 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester.

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Kawakami, Yuji. (2017). Process for preparing 3-[(s)-7-bromo-2-((2-oxopropyl)amino)-5-pyridin-2-yl-3h-1,4-benzodiazepin-3-yl]propionic acid methyl ester (U.S. Patent No. 9656987). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9656987

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