The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2017
Filed:
Mar. 17, 2015
Alessandra Bartolozzi, Somerville, MA (US);
Stewart Campbell, Framingham, MA (US);
Hope Foudoulakis, Framingham, MA (US);
Enoch Kim, Boston, MA (US);
Paul Sweetnam, Marblehead, MA (US);
Yingfei Yang, Belmont, MA (US);
Alessandra Bartolozzi, Somerville, MA (US);
Stewart Campbell, Framingham, MA (US);
Hope Foudoulakis, Framingham, MA (US);
Enoch Kim, Boston, MA (US);
Paul Sweetnam, Marblehead, MA (US);
Yingfei Yang, Belmont, MA (US);
Surface Logix, Inc., Brighton, MA (US);
Abstract
The present invention relates to compounds which are inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion. These compounds can be useful for the prevention and treatment of various diseases, particularly atherosclerosis and its clinical sequelae, for lowering serum lipids, and related ailments. The invention further relates to pharmaceutical compositions comprising the compounds and to methods of treating diseases, such as hypertriglyceridemia, hyperchylomicronemia, atherosclerosis, obesity, and related conditions using the compounds. A method for decreasing apolipoprotein B (apo B) secretion is also provided.