The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2017
Filed:
Jan. 16, 2014
Applicant:
Merck Patent Gmbh, Darmstadt, DE;
Inventors:
Markus Klein, Darmstadt, DE;
Sven Lindemann, Darmstadt, DE;
Assignee:
MERCK PATENT GMBH, Darmstadt, DE;
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); A61K 31/337 (2006.01); A61K 31/415 (2006.01); A61K 31/426 (2006.01); A61K 31/4406 (2006.01); A61K 31/451 (2006.01); A61K 31/495 (2006.01); A61K 31/4965 (2006.01); C07C 237/22 (2006.01); C07D 213/81 (2006.01); C07D 213/82 (2006.01); C07D 233/64 (2006.01); C07D 241/12 (2006.01); C07D 241/24 (2006.01); C07C 233/83 (2006.01); C07D 277/30 (2006.01); C07D 277/56 (2006.01); C07D 211/34 (2006.01); C07D 213/40 (2006.01); C07D 213/56 (2006.01); C07D 305/08 (2006.01); A61K 31/197 (2006.01); C07D 211/66 (2006.01); C07D 231/12 (2006.01); C07D 295/215 (2006.01);
U.S. Cl.
CPC ...
C07C 237/22 (2013.01); A61K 31/197 (2013.01); A61K 31/337 (2013.01); A61K 31/415 (2013.01); A61K 31/426 (2013.01); A61K 31/4406 (2013.01); A61K 31/451 (2013.01); A61K 31/495 (2013.01); A61K 31/4965 (2013.01); C07C 233/83 (2013.01); C07D 211/34 (2013.01); C07D 211/66 (2013.01); C07D 213/40 (2013.01); C07D 213/56 (2013.01); C07D 213/81 (2013.01); C07D 213/82 (2013.01); C07D 231/12 (2013.01); C07D 233/64 (2013.01); C07D 241/12 (2013.01); C07D 241/24 (2013.01); C07D 277/30 (2013.01); C07D 277/56 (2013.01); C07D 295/215 (2013.01); C07D 305/08 (2013.01);
Abstract
The present invention relates to compounds of the formula I and in particular medicaments comprising at least one compound of the formula I for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which ADAMTS5 is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, hepatocirrhosis, traumatic cartilage injuries, pain, allodynia or hyperalgesia.