IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9656945 B1

PDFFull Text
Date of Patent:
May. 23, 2017

Filed:

Dec. 22, 2011

3-acyl-ingenols ii

Applicants:

Gunnar Grue-sørensen, Ballerup, DK;

Xifu Liang, Ballerup, DK;

Thomas Högberg, Ballerup, DK;

Kristoffer Månsson, Ballerup, DK;

Per Vedsø, Ballerup, DK;

Inventors:

Gunnar Grue-Sørensen, Ballerup, DK;

Xifu Liang, Ballerup, DK;

Thomas Högberg, Ballerup, DK;

Kristoffer Månsson, Ballerup, DK;

Per Vedsø, Ballerup, DK;

Assignee:

LEO LABORATORIES LIMITED, Dublin, IE;

Attorney:

Birch, Stewart, Kolasch & Birch, LLP

Primary Examiner:

Kendra D Carter

Int. Cl.
CPC ...
C07C 69/013 (2006.01); C07C 69/74 (2006.01); C07C 69/75 (2006.01); C07C 69/753 (2006.01); C07C 69/76 (2006.01); C07C 69/78 (2006.01); C07C 69/92 (2006.01); A61K 31/215 (2006.01); A61K 31/235 (2006.01); A61K 31/245 (2006.01); C07C 229/56 (2006.01); C07C 229/58 (2006.01); C07C 229/64 (2006.01); C07C 233/54 (2006.01); C07C 255/46 (2006.01); A61K 31/277 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07C 69/74 (2013.01); A61K 31/215 (2013.01); A61K 31/235 (2013.01); A61K 31/245 (2013.01); A61K 31/277 (2013.01); A61K 45/06 (2013.01); C07C 69/013 (2013.01); C07C 69/75 (2013.01); C07C 69/753 (2013.01); C07C 69/76 (2013.01); C07C 69/78 (2013.01); C07C 69/92 (2013.01); C07C 229/56 (2013.01); C07C 229/58 (2013.01); C07C 229/64 (2013.01); C07C 233/54 (2013.01); C07C 255/46 (2013.01); C07C 2101/02 (2013.01); C07C 2101/04 (2013.01); C07C 2101/08 (2013.01); C07C 2101/14 (2013.01); C07C 2101/16 (2013.01); C07C 2103/86 (2013.01);
Abstract

The invention relates to compounds of general formula I, (I), wherein R is wherein R is aryl substituted by R3; or R is (C3-Ci3)-cycloalkyl, (C3-Ci3)-cycloalkenyl or (C7-Ci3)-cycloalkynyl optionally substituted by R4; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.

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